ANTIBREAST CANCER ACTIVITY OF NANOPROPOLIS INDONESIA ON INDUCED MAMMARY GLAND TUMOR BY DMBA IN VIRGIN SPRAGUE-DAWLEY RATS

Authors

  • Akhmad Endang Zainal Hasan Institut Pertanian Bogor
  • Djumali Mangunwidjaja
  • Titi Candra Sunarti
  • Ono Suparno
  • Agus Setiyono

DOI:

https://doi.org/10.11598/btb.2016.23.1.473

Abstract

The objective of this study was to determine the effect of nanopropolis to cure cancer induced on rat mammary tumor using 7,12-dimethylbenz(a)anthracene (DMBA). After the first tumors appearance, twenty eight rats were divided into seven groups. Group 1, 2 and 3 served as recipient of nanopropolis dosages 8, 32 and 56 µg/mL treatments; Group 4 served asrecipient of propolis dosage of 233 µg/mL treatment; Group 5 served asrecipient of doxorubicin treatment; Group 6 served as recipient of DMBA treatment and Group 7 as normal group (control). The effect of nanopropolis dosage of 32 µg/mL and propolis dosage of 233 µg/mL were similar in reducing tumor size, healing the wounds caused by the tumor and eliminating cancer cells. It turns out that there is a relationship between particle size absorbent materials. The study suggested that nanopropolis with small concentration was very effective to treatrat mammary gland tumors and breast cancers.Keywords: breast cancer, nanopropolis, propolis, Sprague-Dawley rat

Author Biography

Akhmad Endang Zainal Hasan, Institut Pertanian Bogor

Department of Biochemistry, Bogor Agricultural University

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Published

2016-08-03

Issue

Vol. 23 No. 1 (2016)

Section

Research Paper

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