HISTOPATHOLOGY OF THE TELENCEPHALON AND DIENCEPHALON OF T1LAPIA NILOTICA EXPOSED TO SUBLETHAL DOSE OF MALATHION S-[1,2-DI-(ETHOXYCARBONYL ETHYL) DIMETHYL PHOSPHOROTHIOLOTHIONATE]

EDNA A AMPARADO

Abstract


A  35-day  exposure  of  Tilapia  nilotica  embryos  to  sublethal  doses  of  3.0  ppm  and  0.3  ppm
malathion,  S-[l,2-di-(ethoxycarbonyl  ethyl)  dimethyl  phosphorothiolothionate],  commercial  grade,  EC  57,
produces cellular and ultrastructure changes in the brain. A number of nuclear centers of the treated animals are
markedly larger than those of the control. Aberrant features observed in day-45 embryos are the neoplastic
masses and increased vascularization. Ultrastructure defects include the presence of nuclear blebs, cytoplasmic
vacuolations and increased lysosomal bodies.

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DOI: http://dx.doi.org/10.11598/btb.1992.0.5.195

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