THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus)

Abstract

The investigation of the effects of a-chlorohydrin on the gestation of the wistar rat has been
carried out to determine whether a-chlorohydrin could interfere with the gestation of the rat and
gestation period for optimal sensitivity. Alpha-chlorohydrin was administered by gavage to three
different groups of pregnant rats, namely on the first (pre-implantation period), sixth (early post-
implantation period) or fourteenth (late post-implantation period) gestation day, at a single dose of 62.5; 75
and 90 mg/kg body weight. Rats were sacrificed on  the IS* gestation day. Number of implantations,
gestation loss and post-implantation mortality were recorded. The results revealed that 75 and 90 mg/kg
body weight of a-chlorohydrin significantly interfered with all the gestation periods used. For the pre-
implantation group, a-chlorohydrin decreased significantly the implantation number, but increased the
gestation loss as well as the post-implantation mortality compared to the control groups. For the early
post-implantation and late post-implantation groups, a-chlorohydrin caused a significant increase in
post-implantation mortality compared to the control groups. From these results it is concluded that a-
chlorohydrin at 75 and 90 mg/kg body weight influences the gestation of the wistar rat administered
during the pre-implantation period as the most sensitive gestation period.
Key words  : a-chlorohydrin//tattu? norvegi'ctu/rat/pre-implantation/early post-implantation/late post-
implantation/implantation/gestation loss/post-implantation mortality.