ANTIBREAST CANCER ACTIVITY OF NANOPROPOLIS INDONESIA ON INDUCED MAMMARY GLAND TUMOR BY DMBA IN VIRGIN SPRAGUE-DAWLEY RATS

Akhmad Endang Zainal Hasan, Djumali Mangunwidjaja, Titi Candra Sunarti, Ono Suparno, Agus Setiyono

Abstract


The objective of this study was to determine the effect of nanopropolis to cure cancer induced on rat mammary tumor using 7,12-dimethylbenz(a)anthracene (DMBA). After the first tumors appearance, twenty eight rats were divided into seven groups. Group 1, 2 and 3 served as recipient of nanopropolis dosages 8, 32 and 56 µg/mL treatments; Group 4 served asrecipient of propolis dosage of 233 µg/mL treatment; Group 5 served asrecipient of doxorubicin treatment; Group 6 served as recipient of DMBA treatment and Group 7 as normal group (control). The effect of nanopropolis dosage of 32 µg/mL and propolis dosage of 233 µg/mL were similar in reducing tumor size, healing the wounds caused by the tumor and eliminating cancer cells. It turns out that there is a relationship between particle size absorbent materials. The study suggested that nanopropolis with small concentration was very effective to treatrat mammary gland tumors and breast cancers.

Keywords: breast cancer, nanopropolis, propolis, Sprague-Dawley rat


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DOI: http://dx.doi.org/10.11598/btb.2016.23.1.473

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